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Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
498
Issue
2
Identifiers
DOI: 10.1016/0006-8993(89)91121-9
Keywords
  • Aluminum
  • Neurotoxicity
  • Choline
  • Norepinephrine
  • Rat Hippocampus

Abstract

Abstract The effects of the intraventricular administration of aluminum chloride (AlCl 3) on high affinity choline transport (HAChT) and norepinephrine concentration were examined in the hippocampus of the rat. Controlling for osmolarity and pH, the intraventricular administration of AlCl 3 resulted in a dose-related reduction in both variables with relative selectivity for HAChT. Moreover, the neurotoxicity of intraventricular aluminum appeared to be dependent on the form of the aluminum salt administered.

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