Affordable Access

Ribosomal Protein Metallopanstimulin-1 Impairs Multiple Myeloma CAG Cells Growth and Inhibits Fibroblast Growth Factor Receptor 3

Authors
Publisher
Elsevier Inc.
Volume
11
Issue
6
Identifiers
DOI: 10.1016/j.clml.2011.06.015
Keywords
  • Fibroblast Growth Factor Receptor (Fgfr3)
  • Metallopanstimulin-1
  • Multiple Myeloma
  • Rps27

Abstract

Abstract Introduction It was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression. Methods The present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo. Results Overexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1. Conclusions These data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.

There are no comments yet on this publication. Be the first to share your thoughts.