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S-Oxalylglutathione is a substrate for γ-glutamyltransferase (GGT). Implications for the role of GGT in cell proliferation

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
150
Issue
2
Identifiers
DOI: 10.1016/0006-291x(88)90466-4

Abstract

Abstract With glycylglycine or water as acceptor, bovine kidney γ-glutamyltransferase catalyzes reactions of the known mammalian metabolite, S-oxalylglutathione, at rates comparable to those of L-γ-glutamyl-p-nitroanilide, a known good substrate. N-Oxalylcysteinylglycine is the eventual product of the former reaction. Since oxalyl thiolesters are implicated as important cell proliferation inhibitors, it is proposed that this reaction plays a major role in controlling cell proliferation.

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