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Morphological observations on the cytotoxicity of human blood lymphocytes for antibody-coated chicken erythrocytes

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
62
Identifiers
DOI: 10.1016/0014-4827(70)90574-4

Abstract

Abstract Chicken erythrocytes, treated with sublytical concentration of heat inactivated rabbit antiserum, are destroyed by highly purified human peripheral blood lymphocytes. Morphological evidence supports the notion that the target cells are killed by a mechanism involving osmotic lysis. Opsonification of the target cells elicits a phagocytic activity of some cells with characteristic lymphocyte morphology. However, phagocytosis appears to be of minor importance for the cytotoxic reaction.

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