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Comportement métabolique de Lactococcus lactis en réponse à l'environnement

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  • [Sdv:Aen] Life Sciences/Food And Nutrition
  • [Sdv:Aen] Sciences Du Vivant/Alimentation Et Nutrition
  • [Sdv:Ida] Life Sciences/Food Engineering
  • [Sdv:Ida] Sciences Du Vivant/Ingénierie Des Aliments
  • Ecology
  • Geography
  • Medicine


Lait (1998) 78, 145-155 © Inra/Elsevier, Paris 145 Comportement métabolique de Lactococcus lactis en réponse à l'environnement Christel Garrigues, Myriam Mercade, Pascal Loubière, Nic D. Lindley, Muriel Cocaign-Bousquet* Centre de bio-ingénierie Gilbert-Durand. UMR CNRS/lnsa 5504, laboratoire associé Inra, Institut national des sciences appliquées, complexe scientifique de Rangueil, 31077 Toulouse cedex 4, France Abstract - Metabolic behavlour of Lactococcus lactis in response to environmental conditions. Growth and metabolism of the lactic acid bacteria are closely dependent on the nutritional environment. Major environ mental constraints, when they are not directly related to the bacterial growth, are the nature and the availability of the nitrogen and carbon sources. ln this paper, the influence of the carbon substrate (sugar) on the metabolism of Lactococcus lactis NCDO 2118 was studied from a kinetic and enzymatic point of view. An original model of metabolism control has been developed and was successively tesied in other nutritional environments. This model differs from that generally assumed for lactic acid bacteria and can be applied to other lactococci. Fructose-J .ô-bisphosphate plays only a minor role in controlling the further metabolism of pyruvate and NADH/NAD ratio exerts the major control over glycolytic flux. The metabolic consequences of co-substrate utilization were analyzed and the role of serine utilization on the metabolism of L. lactis NCDO 2118 was investigated in more detail. © Inra/Elsevier, Paris. Lactococcus lactis / growth / homolactic and mixed metabolism / co-substrate Résumé - La croissance ainsi que le métabolisme des bactéries lactiques sont fortement dépen- dants de l'environnement nutritionnel. Les contraintes environnementales majeures, lorsqu'elles ne sont pas liées à la croissance même du micro-organisme, concernent la nature et la disponibilité de la source d'azote et de carbone. Plus particulièrement, l'effet de la source de carbone (suc

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