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Identification of impurities in ivermectin bulk material by mass spectrometry and NMR

Authors
Journal
Journal of Pharmaceutical and Biomedical Analysis
0731-7085
Publisher
Elsevier
Publication Date
Volume
41
Issue
4
Identifiers
DOI: 10.1016/j.jpba.2006.02.021
Keywords
  • Hplc
  • Ivermectin
  • Avermectin
  • Process Impurities
  • Nmr
  • Ms

Abstract

Abstract The identification and characterization of four process impurities in bulk ivermectin and four process impurities in bulk avermectin, using a combination of MS and NMR, are discussed herein. These process impurities were shown to be 24-demethyl H 2B 1a, 3′-demethyl H 2B 1a, 3″-demethyl H 2B 1a and 24a-hydroxy B 2a isomer. The impurities were shown to be process impurities and are present in avermectin bulk also.

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