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Synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) analogs

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
62
Issue
13
Identifiers
DOI: 10.1016/j.tet.2006.01.025
Keywords
  • Nucleotides
  • Phosphoramidites
  • Cyclization
  • C-Di-Gmp
Disciplines
  • Design

Abstract

Abstract This paper reports the synthesis of cyclic bis(3′-5′)diguanylic acid ( c-di-GMP) analogs, including the monophosphorothioic acid of c-di-GMP ( c-GpGps), cyclic bis(3′-5′)guanylic/adenylic acid ( c-GpAp), and cyclic bis(3′-5′)guanylic/inosinic acid ( c-GpIp). These compounds are expected to be important, both in elucidating the mechanism of bioactive c-di-GMP and in designing and creating new bioactive c-di-GMP-related artificial derivatives.

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