Affordable Access

Exocytosis: The Chromaffin Cell As a Model System

Annals of the New York Academy of Sciences
Wiley Blackwell (Blackwell Publishing)
Publication Date
  • Biology
  • Chemistry
  • Medicine
  • Physics


Neurons and neuroendocrine cells release transmitters and hormones by exocytosis of secrctory vesicles or granules. Among the cell models that have provided insight into the molecular machinery underlying the successive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Thus, most of the molecular players that orchestrate the formation, targeting, docking, and fusion of secrctory granules have been identified in chromaffin cells. By offering the opportunity to combine the use of recent biophysical techniques allowing single-vesicle resolution and specific biochemical modifications in the protein machinery involved in exocytosis, chromaffn cells remain a powerful model to address new and still open questions in the field of secretion.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Exocytosis: the chromaffin cell as a model system.

on Annals of the New York Academy... October 2002

Molecular mechanisms of exocytosis: the adrenal ch...

on Cellular and Molecular Neurobi... March 1988

Development of a cell-free model for compound exoc...

on Journal of the autonomic nervo... January 1983

Development of a cell-free model for compound exoc...

on Journal of the Autonomic Nervo... Jan 01, 1983
More articles like this..