Affordable Access

Publisher Website

Decision-making and neuroendocrine responses in pathological gamblers

Authors
Journal
Psychiatry Research
0165-1781
Publisher
Elsevier
Publication Date
Volume
153
Issue
3
Identifiers
DOI: 10.1016/j.psychres.2007.02.002
Keywords
  • Decision-Making
  • Pathological Gambling
  • Cortisol
  • Alpha-Amylase
Disciplines
  • Biology
  • Chemistry
  • Medicine
  • Psychology

Abstract

Abstract Recent neuropsychological research indicates that patients with pathological gambling (PG) exhibit deficits in laboratory tasks of decision-making which are suggested to be associated with neurochemical alterations within the prefrontal cortex. Some studies also revealed that hypothalamic–pituitary–adrenal axis activity in gamblers is altered. To date, very little is known about the relationship between decision-making and neuroendocrine parameters. Therefore, we examined patients with PG ( n = 22) and healthy comparison subjects ( n = 19) with a laboratory task of decision-making (Game of Dice Task) and sampled salivary cortisol and alpha-amylase (sAA) concentrations before and in the course of task performance. Results showed that the PG patients’ neuroendocrine responses were comparable to those of the healthy subjects, even though the patients had severe decision-making deficits. Within both groups, there were no changes in cortisol and sAA responses. However, correlations and a subgroup analysis for sAA revealed that only those patients who showed less disadvantageous decision-making patterns had an increase of sAA during the task. Accordingly, the increase of sAA – as an indirect marker of sympathetic nervous system activity – in those patients with less severe decision-making deficits could reflect the use of somatic markers biasing the decision-making process.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The impact of alexithymia on pathological gamblers...

on Cognitive and behavioral neuro... June 2014

Psychophysiological determinants and concomitants...

on Drug and Alcohol Dependence Jan 01, 2006
More articles like this..