Abstract In this paper, we consider the problem of synchronizing a master–slave chaotic system in the sampled-data setting. We consider both the intermittent coupling and continuous coupling cases. We use an Euler approximation technique to discretize a continuous-time chaotic oscillator containing a continuous nonlinear function. Next, we formulate the problem of global asymptotic synchronization of the sampled-data master–slave chaotic system as equivalent to the states of a corresponding error system asymptotically converging to zero for arbitrary initial conditions. We begin by developing a pulse-based intermittent control strategy for chaos synchronization. Using the discrete-time Lyapunov stability theory and the linear matrix inequality (LMI) framework, we construct a state feedback periodic pulse control law which yields global asymptotic synchronization of the sampled-data master–slave chaotic system for arbitrary initial conditions. We obtain a continuously coupled sampled-data feedback control law as a special case of the pulse-based feedback control. Finally, we provide experimental validation of our results by implementing, on a set of microcontrollers endowed with RF communication capability, a sampled-data master–slave chaotic system based on Chua’s circuit.