Affordable Access

The Modifying Influence of Diet and the Physical Environment on Spontaneous Tumour Frequency in Rats

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Articles
  • Ecology
  • Geography


565 THE MODIFYING INFLUENCE OF DIET AND THE PHYSICAL ENVIRONMENT ON SPONTANEOUS TUMOUR FREQUENCY IN RATS CHRISTINE GILBERT, J. GILLMAN, P. LOUSTALOT AND W. LUTZ From the Department of Physiology, and C.S.I.R Nutrition Research Unit of the University of the Witwatersrand, Johannesburg; the Research Laboratories of the Pharmaeutical Department of CIBA Limited, Basle; and the Department of Statistics, University of the Witwatersrand, Johannesburg Received for publication August 11, 1958 THE unusually high frequency of phaeochromocytoma in albino Wistar strain rats bred for many years in our laboratory in Johannesburg compared with that reported from the Wistar Institute by Yeakel (1947) suggested that environmental factors among other conceivable factors were able to influence the development of spontaneous neoplasms in the albino rat (Gillman et al. 1953). It is known that diet can modify the speed of emergence of neoplasms induced experimentally by means of specific carcinogens (Rusch, 1944; Tannenbaum, 1944; Yamagiwa and Itchikawa, 1914; Berenblum, 1954). However, apart from the classical work of McCay (1942) and of Saxton et al. (1948) there is little information about the influence of diet on the frequency of spontaneously-occurring neoplasms in the rat. Moreover, despite its widespread use for studies on experimental cancer, there is a singular lack of statistical information about the risk to cancer of the rat living under a diversity of environmental conditions in different parts of the world. Although it was our original purpose to examine the effects of diet and of geo- graphical factors on the frequency of phaeochromocytoma, the present investiga- tion has been broadened to include a statistical analysis of the kind and frequency as well as the age and sex distribution of other spontaneously-occurring neoplasms. In the presentation of the data, we shall set on record, first, the tumour frequency in terms of age and sex in 586 of our own albino rats (henceforth referred to as the

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times