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An improved method for the determination of leukocyte arylsulfatase A and its application to the diagnosis of metachromatic leukodystrophy in homozygous and heterozygous states

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
39
Issue
2
Identifiers
DOI: 10.1016/0009-8981(72)90081-2
Disciplines
  • Biology
  • Medicine

Abstract

Abstract An improved method for the determination of arylsulfatase A, based on the ether solubility of 4-nitrocatechol, has been established. The method has been applied to the diagnosis of metachromatic leukodystrophy and can identify the carrier state. The method is also useful in organ surveys for the enzyme.

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