Affordable Access

Publisher Website

Sr2+induce a release of divalent cation from internal Ca2+store by nerve stimulation at frog neuromuscular junction

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
275
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(99)00767-3
Keywords
  • Transmitter Release
  • Internal Ca2+Store
  • Sr2+
  • Paired-Pulse Facilitation
Disciplines
  • Biology

Abstract

Abstract The effects of Sr 2+ on the transmitter release at the frog neuromuscular junction were examined electrophysiologically. The nerve trunk was stimulated by paired pulses at various time intervals after replacing extracellular Ca 2+ by Sr 2+, the paired-pulse facilitation at the 10 ms interval was smaller than that at 20–30 ms intervals. Administration of several intracellular Ca 2+ mobilizers decreased the paired-pulse facilitation. These results suggest that the transmitter release in Sr 2+ solution is caused, at least partly, by the release of divalent cations from the intracellular stores.

There are no comments yet on this publication. Be the first to share your thoughts.