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Synthesis of imidazobenzazepinthiones: A new series of HIV-1 reverse transcriptase inhibitors

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
36
Issue
9
Identifiers
DOI: 10.1016/0040-4039(95)00006-x

Abstract

Abstract A general route to a series of novel imidazobenzazepines that are “carba” analogs of the TIBO class of non-nucleoside HIV-1 reverse transcriptase inhibitors has been developed. A pair of allyl side-chain containing compounds were found to have significant HIV-1 inhibitory activity.

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