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Determinants of trophoblast lineage and cell subtype specification in the mouse placenta

Authors
Journal
Developmental Biology
0012-1606
Publisher
Elsevier
Publication Date
Volume
284
Issue
1
Identifiers
DOI: 10.1016/j.ydbio.2005.05.010
Keywords
  • Trophoblast Lineage
  • Subtype Specification
  • Mouse Placenta
  • Stem Cell Maintenance
Disciplines
  • Biology

Abstract

Abstract Cells of the trophoblast lineage make up the epithelial compartment of the placenta, and their rapid development is essential for the establishment and maintenance of pregnancy. A diverse array of specialized trophoblast subtypes form throughout gestation and are responsible for mediating implantation, as well as promotion of blood to the implantation site, changes in maternal physiology, and nutrient and gas exchange between the fetal and maternal blood supplies. Within the last decade, targeted mutations in mice and the study of trophoblast stem cells in vitro have contributed greatly to our understanding of trophoblast lineage development. Here, we review recent insights into the molecular pathways regulating trophoblast lineage segregation, stem cell maintenance, and subtype differentiation.

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