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Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
39
Issue
16
Identifiers
DOI: 10.1016/0024-3205(86)90552-7
Disciplines
  • Medicine

Abstract

Abstract Effects of mexiletine and lidocaine on inward calcium current (I Ca) of single ventricular myocytes from guinea pigs were studied using tight seal whole cell clamp method. Mexiletine at the concentrations of 10, 30 and 100 μM decreased I Ca by 23.0, 28.9 and 55.4 %, respectively, while lidocaine decreased it by 8.9, 16.8 and 25.2 %. At all concentrations tested, a potency for I Ca inhibition in mexiletine was significantly greater than that in lidocaine (p<0.05). The results suggest that mexuletine has, at therapeutic concentrations, a considerable blocking action on the Ca channels other than well-known action on the Na channels.

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