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Race/ethnicity and disease severity in IgA nephropathy

BioMed Central
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  • Biology
  • Medicine

Abstract ral ss BioMed CentBMC Nephrology Open AcceResearch article Race/ethnicity and disease severity in IgA nephropathy Yoshio N Hall*1, Eloisa F Fuentes2, Glenn M Chertow*1 and Jean L Olson2 Address: 1Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA and 2Department of Pathology, University of California San Francisco, San Francisco, CA, USA Email: Yoshio N Hall* - [email protected]; Eloisa F Fuentes - [email protected]; Glenn M Chertow* - [email protected]; Jean L Olson - [email protected] * Corresponding authors Abstract Background: Relatively few U.S.-based studies in chronic kidney disease have focused on Asian/ Pacific Islanders. Clinical reports suggest that Asian/Pacific Islanders are more likely to be affected by IgA nephropathy (IgAN), and that the severity of disease is increased in these populations. Methods: To explore whether these observations are borne out in a multi-ethnic, tertiary care renal pathology practice, we examined clinical and pathologic data on 298 patients with primary glomerular lesions (IgAN, focal segmental glomerulosclerosis, membranous nephropathy and minimal change disease) at the University of California San Francisco Medical Center from November 1994 through May 2001. Pathologic assessment of native kidney biopsies with IgAN was conducted using Haas' classification system. Results: Among individuals with IgAN (N = 149), 89 (60%) were male, 57 (38%) white, 53 (36%) Asian/Pacific Islander, 29 (19%) Hispanic, 4 (3%) African American and 6 (4%) were of other or unknown ethnicity. The mean age was 37 ± 14 years and median serum creatinine 1.7 mg/dL. Sixty- six patients (44%) exhibited nephrotic range proteinuria at the time of kidney biopsy. The distributions of age, gender, mean serum creatinine, and presence or absence of nephrotic proteinuria and/or hypertension at the time of kidney biopsy were not significantly different among white, H

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