Affordable Access

Publisher Website

Membrane lipid changes and modification of neuronal function homeostasis in aging brain

Authors
Journal
Neurobiology of Aging
0197-4580
Publisher
Elsevier
Publication Date
Volume
5
Issue
4
Identifiers
DOI: 10.1016/0197-4580(84)90015-0
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Three issues are raised which may be relevant to changes in membrane asymmetry, but were not discussed in Schroeder's review: (1) In addition to the contribution of phospholipids and cholesterol in the maintenance of membrane properties and homeostasis, gangliosides also play an important role, particularly in membrane-mediated transfer of information. (2) Increasing evidence implicates a dynamic interaction between neurons and glia in brain function. The functional integrity and homeostasis of this neural/glial interaction could be seriously affected by any number of changes in membrane lipid content and distribution. (3) In addition to the functional implications of lipid asymmetry reviewed by Schroeder, alterations in the asymmetrical distribution of phosphatidylserine may activate certain defense reactions. These reactions may possess their own inherent neural functional consequences, providing certain implications for pharmacological treatment.

There are no comments yet on this publication. Be the first to share your thoughts.