Abstract Three issues are raised which may be relevant to changes in membrane asymmetry, but were not discussed in Schroeder's review: (1) In addition to the contribution of phospholipids and cholesterol in the maintenance of membrane properties and homeostasis, gangliosides also play an important role, particularly in membrane-mediated transfer of information. (2) Increasing evidence implicates a dynamic interaction between neurons and glia in brain function. The functional integrity and homeostasis of this neural/glial interaction could be seriously affected by any number of changes in membrane lipid content and distribution. (3) In addition to the functional implications of lipid asymmetry reviewed by Schroeder, alterations in the asymmetrical distribution of phosphatidylserine may activate certain defense reactions. These reactions may possess their own inherent neural functional consequences, providing certain implications for pharmacological treatment.