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Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis

Pulsus Group Inc
Publication Date
  • Original Article


Taurine is a beta-amino acid that is found in excitable tissues; however, its deficiency leads to reduced ATP generation and oxidative stress, and contributes to cell shrinkage during apoptosis. In addition, taurine has been found to modulate calcium movement and superoxide generation, which are important to cell survival. Accordingly, this study examined the involvement of reactive oxygen species and calcium movement in the initiation of cellular apoptosis by testing the taurine content of neonatal cardiomyocytes (isolated from two- to three-day-old Wistar rats) after 48 h incubation in medium containing the taurine transport inhibitor beta-alanine.

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