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Amniotic fluid concentrations of adrenomedullin in preterm labor

Authors
Journal
Obstetrics and Gynecology
0029-7844
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
93
Issue
6
Identifiers
DOI: 10.1016/s0029-7844(98)00551-1
Disciplines
  • Medicine

Abstract

Abstract Objective: To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor. Methods: We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women. Results: Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 ± 22.5 pg/mL and 182.7 ± 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 ± 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 ± 26.8 pg/mL). Conclusion: Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.

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