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Effects on experimental animals of long-term inhalation exposure to mineral spirits

Authors
Journal
Toxicology and Applied Pharmacology
0041-008X
Publisher
Elsevier
Publication Date
Volume
9
Issue
2
Identifiers
DOI: 10.1016/0041-008x(66)90120-7
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract A series of short-term repeated and long-term continuous inhalation studies were conducted with a widely used Navy paint thinner (mineral spirits) at concentrations ranging from 114 to 1353 mg/m 3. Guinea pigs exposed continuously for 90 days to 363–1271 mg/m 3 showed mortality rates ranging from 27 to 79%. Hematologic, biochemical, and pathologic studies failed to reveal changes that might account for these deaths. On the basis of these studies a 90-day tentative guideline for submarines has been established at 40 mg/m 3 for mineral spirits containing 15–20% aromatic hydrocarbons.

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