Affordable Access

Publisher Website

Principles: A model for the allosteric interactions between ligand binding sites within a dimeric GPCR

Authors
Journal
Trends in Pharmacological Sciences
0165-6147
Publisher
Elsevier
Publication Date
Volume
26
Issue
7
Identifiers
DOI: 10.1016/j.tips.2005.05.006
Disciplines
  • Biology
  • Mathematics

Abstract

Increasing evidence suggests that most, if not all, G-protein-coupled receptors have the propensity to dimerize. The dimerization process can lead to crosstalk between the protomers and can result in cooperative binding of ligands to these protomers. However, many results suggest that the crosstalk between protomers within a dimer is not permanent. Receptors oscillate between two states: one that enables binding sites to crosstalk and another that does not enable such crosstalk. In this article, the consequences of the equilibrium between these two states on the binding properties of a receptor are analyzed using the predictions of two mathematical models.

There are no comments yet on this publication. Be the first to share your thoughts.