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Reconstructed human epidermis: A model to study the barrier function

Authors
Journal
Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms
0168-583X
Publisher
Elsevier
Publication Date
Volume
231
Identifiers
DOI: 10.1016/j.nimb.2005.01.072
Keywords
  • Reconstructed Human Epidermis
  • Skin
  • Nuclear Microscopy
  • Micro-Pixe
Disciplines
  • Biology
  • Pharmacology
  • Philosophy

Abstract

Abstract The use of in vitro reconstructed human epidermis (RHE) by the cosmetic and pharmaceutical industries is increasing because of its similar physiological mechanisms to native human skin. With the advent of ethic laws on animal experimentation, RHE provides an helpful alternative for the test of formulations. The aim of this study is to check that the RHE mineral status is comparable to that of human native skin by investigating the elemental distributions in the epidermis strata. In addition, possible deleterious effects of the transport on the epidermis ionic content were studied by nuclear microscopy.

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