Affordable Access

Publisher Website

Chronic experimental allergic encephalomyelitis in rhesus monkeys and its modification by treatment

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
38
Issue
3
Identifiers
DOI: 10.1016/0022-510x(78)90136-3
Disciplines
  • Medicine

Abstract

Abstract Rhesus monkeys were immunized with low doses of encephalitogenic mixture. Twenty two of 24 monkeys developed experimental allergic encephalomyelitis (EAE) lasting from 3 to 252 days. Fifteen of 22 monkeys developed chronic progressive EAE with remissions and relapses. In the early stages of EAE multiple perivascular foci of demyelination and lymphoid histiocytic infiltration were found within the central nervous system (CNS). In advanced disease these foci became confluent, developing foci of plaque type with demyelination and gliofibrosis. Eight affected monkeys received an emulsion of spinal cord with incomplete adjuvant; 6 of them showed a good therapeutic response. In the CNS of those monkeys 514 to 667 days later plaques of demyelination and gliofibrosis and minimal inflammatory lesions were detected. Two monkeys without clinical evidence of EAE had plaques of demyelination and gliofibrosis in the CNS 2 years after immunization. It is suggested that chronic EAE in monkeys may be considered an adequate model for multiple sclerosis (MS).

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Chronic experimental allergic encephalomyelitis in...

on Journal of the Neurological Sc... October 1978

Diagnosis and treatment of experimental allergic e...

on Transactions of the American N... 1974

Experimental allergic encephalomyelitis in rhesus...

on Clinical & Experimental Immuno... May 1987

[Chronic experimental allergic encephalomyelitis i...

on Zhurnal nevropatologii i psikh... 1982
More articles like this..