The results of response estimation of microbial associations on heavy metal pollution of coastal waters of northern Primorye, Peter the Great Bay (off Tumannaya river mouth), Kamchatka (Avachinskaya Guba) and northeastern coast of Sakhalin Island are presented. The data were compared with corresponding results of chemical analysis. The goal was to estimate the ecological state of investigated regions as regards to heavy metal consistence in sea waters by means of microbial indication, and also to demonstrate the effectiveness of the method for biochemical mapping. The regions with bad ecological situation as regards to heavy metal consistence in sea waters, where percent of metalresistant forms of bacteria was considerable in total quantity of heterotrophic microorganisms, have been revealed on the base of performed investigations. Good possibilities have been demonstrated by using of microbial indication for biochemical mapping on example of two regions of Peter the Great Bay: near Tumannaya river mouth and in the southern part of FarEastern State Marine Reservation.