Affordable Access

Publisher Website

A Roadmap to the Brittle Bones of Cystic Fibrosis

Authors
Journal
Journal of Osteoporosis
2090-8059
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2011
Identifiers
DOI: 10.4061/2011/926045
Keywords
  • Review Article
Disciplines
  • Biology
  • Medicine

Abstract

Cystic fibrosis (CF) is an autosomal recessive disorder which despite advances in medical care continues to be a life-limiting and often fatal disease. With increase in life expectancy of the CF population, bone disease has emerged as a common complication. Unlike the osteoporosis seen in postmenopausal population, bone disease in CF begins at a young age and is associated with significant morbidity due to fractures, kyphosis, increased pain, and decreased lung function. The maintenance of bone health is essential for the CF population during their lives to prevent pain and fractures but also as they approach lung transplantation since severe bone disease can lead to exclusion from lung transplantation. Early recognition, prevention, and treatment are key to maintaining optimal bone health in CF patients and often require a multidisciplinary approach. This article will review the pathophysiology, current clinical practice guidelines, and potential future therapies for treating CF-related bone disease.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

No brittle bones.

on Positively aware : the monthly... 2013

'Old' bones in young bodies: the tale of cystic fi...

on Current opinion in endocrinolo... December 2009
More articles like this..