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HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K+-channel currents in murine thymocytes

Authors
Journal
Pharmacological Reports
1734-1140
Publisher
Elsevier
Volume
66
Issue
4
Identifiers
DOI: 10.1016/j.pharep.2014.03.002
Keywords
  • Hmg-Coa Reductase Inhibitors (Statins)
  • Immunosuppressive Effects
  • Lymphocytes
  • Kv1.3-Channel
  • Membrane Capacitance (Cm)

Abstract

Abstract Background Since lymphocytes predominantly express delayed rectifier K+-channels (Kv1.3) that trigger lymphocyte activation, statins, which exert immunosuppressive effects, would affect the channel currents. Methods Employing the patch-clamp technique in murine thymocytes, we examined the effects of statins on Kv1.3-channel currents and the membrane capacitance (Cm). Results Pravastatin significantly suppressed the pulse-end currents of the channels. Lovastatin and simvastatin also suppressed the peak currents, significantly decreasing the Cm. Conclusions This study demonstrated for the first time that statins inhibit thymocyte Kv1.3-channels. The slow inactivation patterns induced by lovastatin and simvastatin may be associated with their accumulation in the plasma membranes.

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