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Physical factors involved in stress-wave-induced cell injury: The effect of stress gradient

Authors
Journal
Ultrasound in Medicine & Biology
0301-5629
Publisher
Elsevier
Publication Date
Volume
21
Issue
7
Identifiers
DOI: 10.1016/0301-5629(95)00027-o
Keywords
  • Ablation
  • Photoacoustics
  • Shock Waves
  • Stress Gradient
  • Cell Viability
  • Membrane Permeability
Disciplines
  • Biology

Abstract

Abstract We have studied the biological effects of ablation-induced stress waves in vitro. Mouse breast sarcoma cells (EMT-6) were exposed to stress waves that differed only in rise time. Two assays were used to determine cell injury: incorporation of tritiated thymidine (viability assay), and transmission electron microscopy (morphology assay). We present evidence that the rise time of stress waves can significantly modify cell viability and that cell injury correlates better with the stress gradient than peak stress.

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