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Chemokines and chemokine receptors: Large and small therapeutic strategies for inflammatory diseases

Authors
Journal
Drug Discovery Today Therapeutic Strategies
1740-6773
Publisher
Elsevier
Publication Date
Volume
3
Issue
3
Identifiers
DOI: 10.1016/j.ddstr.2006.07.003
Disciplines
  • Medicine

Abstract

Chemokines and their receptors function in leukocyte trafficking to sites of inflammation and cellular activation and are attractive therapeutic targets for immune-mediated inflammatory diseases. Developing therapeutics for this family of molecules has proved challenging. Small and large molecule therapeutics are now in development for several key receptor-ligand pairs. Neither strategy has yielded human proof of concept for intervening in this pathway; however, we are now closer than ever to realizing this goal.

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