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Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
469
Identifiers
DOI: 10.1016/s0014-5793(00)01273-4
Keywords
  • Placental Alkaline Phosphatase
  • Insulin
  • Fibroblast
  • Dna Synthesis
  • Mitogen-Activated Protein Kinase
Disciplines
  • Biology

Abstract

Abstract Human placental alkaline phosphatase (PALP) is synthesized in the placenta during pregnancy and is also expressed in many cancer patients; however, its physiological role is unknown. Here we show that in human fetus fibroblasts as well as normal and H-ras-transformed mouse embryo fibroblasts PALP stimulates DNA synthesis and cell proliferation in synergism with insulin, zinc and calcium. The mitogenic effects of PALP are associated with the activation of c-Raf-1, p42/p44 mitogen-activated protein kinases, p70 S6 kinase, Akt/PKB kinase and phosphatidylinositol 3′-kinase. The results suggest that in vivo PALP may promote fetus development as well as the growth of cancer cells which express oncogenic Ras.

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