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An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination

Authors
Journal
Mitochondrion
1567-7249
Publisher
Elsevier
Volume
13
Issue
4
Identifiers
DOI: 10.1016/j.mito.2013.04.011
Keywords
  • Mtdna
  • Haplogroup
  • Determination
  • Scoring System
Disciplines
  • Anthropology
  • Criminology
  • Medicine

Abstract

Abstract The determination of human mitochondrial DNA (mtDNA) haplogroups is not only crucial in anthropological and forensic studies, but is also helpful in the medical field to prevent establishment of wrong disease associations. In recent years, high-throughput technologies and the huge amounts of data they create, as well as the regular updates to the mtDNA phylogenetic tree, mean that there is a need for an automated approach which can make a speedier determination of haplogroups than can be made by using the traditional manual method. Here, we update the MitoTool (www.mitotool.org) by incorporating a novel scoring system for the determination of mtDNA into haplogroups, which has advantages on speed, accuracy and ease of implementation. In order to make the access to MitoTool easier, we also provide a stand-alone version of the program that will run on a local computer and this version is freely available at the MitoTool website.

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