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Mechanism of anti-inflammatory activity of β-adrenoceptor blocking agents

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
20
Issue
3
Identifiers
DOI: 10.1016/0014-2999(72)90199-9
Keywords
  • β-Adrenoceptor Blocking Agents
  • Carrageenin-Induced Oedema
  • Pituitary-Adrenal System

Abstract

Abstract The anti-inflammatory activity of β-adrenoceptor blocking agents viz. K.O. 592, INPEA and propranolol was investigated against carrageenin-induced oedema in albino rats. These compounds showed potent anti-inflammatory activity which was not related to their β-adrenoceptor blocking property. Since, these compounds failed to inhibit carrageenin-induced oedema in hypophysectomized as well as in bilaterally adrenalectomized rats, it seems that their anti-inflammatory activity was due to an activation of pituitary-adrenal system. β-Adrenoceptor blocking agents Carrageenin-induced oedema Pituitary-Adrenal system.

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