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Histamine secretion from mast cells and basophils

Authors
Journal
Trends in Pharmacological Sciences
0165-6147
Publisher
Elsevier
Publication Date
Volume
4
Identifiers
DOI: 10.1016/0165-6147(83)90478-9
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract This paper reviews the biochemical events which accompany basophil/mast cells activation. The bridging of IgE-molecules on the cell surface results in the activation of transmethylation enzymes and the formation of phosphatidylcholine. This is followed by an influx of Ca 2+ into the cell and the activation of phospholipase which acts on phosphatidylcholine to release arachidonic acid. Further steps which include protein phosphorylation result in histamine secretion.

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