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Strain-specific development of the mossy fiber system in organotypic cultures of the mouse hippocampus

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
87
Identifiers
DOI: 10.1016/0304-3940(88)90136-x
Keywords
  • Mouse
  • Hippocampus
  • Mossy Fiber
  • Organotypic Culture
  • Inbred Strain
  • Genetic Variation

Abstract

Abstract The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation of 3–4 weeks, similar strain-specific patterns became apparent in vitro, as visualized by a modified Timm staining. From this experiment we can conclude that a postnatal extrinsic influence cannot be the cause of the strain-specific hippocampal features.

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