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Investigation of striatal dopamine D2receptor acquisition following prenatal neuroleptic exposure

Authors
Journal
Psychiatry Research
0165-1781
Publisher
Elsevier
Publication Date
Volume
36
Issue
3
Identifiers
DOI: 10.1016/0165-1781(91)90030-s
Keywords
  • Dopamine
  • Receptor
  • Development
  • Haloperidol
  • Thiothixene
  • Trifluoperazine

Abstract

Abstract To test the hypothesis that neuroleptic blockade impairs the development of striatal dopamine D 2 receptors, pregnant rats were given haloperidol, thiothixene, or trifluoperazine for gestational days 15–18 (short-term exposure) or days 5–20 (long-term exposure). All of the drugs were demonstrated to cross the placenta and enter the fetal brains equally well. Striatal dopamine D 2 receptors of the pups were assayed on postnatal day 14. Neither receptor density nor receptor affinity was altered significantly by the short- or long-term prenatal neuroleptic treatment.

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