Affordable Access

Publisher Website

Measurement of pulmonary epithelial permeability with99mTc-DTPA aerosol

Authors
Journal
Seminars in Nuclear Medicine
0001-2998
Publisher
Elsevier - WB Saunders
Publication Date
Volume
16
Issue
4
Identifiers
DOI: 10.1016/s0001-2998(86)80014-9
Disciplines
  • Biology
  • Medicine

Abstract

The rate at which inhaled aerosol of 99mTc-diethylenetriamine pentacetate (DTPA) leaves the lung by diffusion into the vascular space can be measured with a gamma camera or simple probe. In normal humans, 99mTc-DTPA clears from the lung with a half time of about 80 minutes. Many acute and chronic conditions that alter the integrity of the pulmonary epithelium cause an increased clearance rate. Thus cigarette smoking, alveolitis from a variety of causes, adult respiratory distress syndrome (ARDS), and hyaline membrane disease (HMD) in the infant have all been shown to be associated with rapid pulmonary clearance of 99mTc-DTPA. Rapid clearance is also promoted by increased lung volume and decreased surfactant activity. Although the mechanism of increased clearance in pathological states is not known, the 99mTc-DTPA lung-clearance technique has great potential clinically, particularly in patients at risk from ARDS and HMD and in the diagnosis and follow-up of alveolitis.

There are no comments yet on this publication. Be the first to share your thoughts.