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Central cardiovascular effects of 6-hydroxydopamine

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
20
Issue
2
Identifiers
DOI: 10.1016/0014-2999(72)90151-3
Keywords
  • 6-Hydroxydopamine
  • Central Cardiovascular Effects
  • Hypothalmic Vasomotor Loci
  • Medullary Vasomotor Loci
  • Scvr
Disciplines
  • Medicine

Abstract

Abstract Effects of 6-hydroxydopamine (6-OHDA) on the vasomotor loci of medulla oblongata, hypothalamus and spinal cord have been investigated in anaesthetized (chloralosed) cats. Intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of 6-OHDA, 0.5–2.0 mg, inhibited reflex, as well as direct, excitability of vasomotor loci. The blood pressure and the heart rate were reduced for a prolonged period. Central tyramine response was blocked while peripheral noradrenaline response remained unaffected. The adrenergic neurones appear to have an excitatory function in central cardiovascular regulation.

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