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Constrained analogues of 2′-nor cyclic nucleoside monophosphates

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
7
Issue
11
Identifiers
DOI: 10.1016/s0960-894x(97)00245-x

Abstract

Abstract The synthesis of constrained analogues of 2′-nor-cyclic nucleosides monophosphates containing a thiomethylene tether was readily accomplished from the oxathiolane intermediate 4. The uracil, cytosine, and 5-bromocytosine spirophosphate analogues 22, 16, and 25 were inhibitory to HCMV replication in Flow 2002 cells.

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