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Single-feature polymorphism discovery in the barley transcriptome

Authors
Journal
Genome Biology
1465-6906
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1186/gb-2005-6-6-r54
Keywords
  • Method
Disciplines
  • Biology

Abstract

A probe-level model for analysis of GeneChip gene-expression data is presented which identified more than 10,000 single-feature polymorphisms (SFP) between two barley genotypes. The method has good sensitivity, as 67% of known single-nucleotide polymorphisms (SNP) were called as SFPs. This method is applicable to all oligonucleotide microarray data, accounts for SNP effects in gene-expression data and represents an efficient and versatile approach for highly parallel marker identification in large genomes.

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