Affordable Access

Antibody response to routine measles vaccination among a population of Nigerian children and evaluation of vaccine potency

Paediatric Association of Nigeria
Publication Date


Background: Despite a global decline in mortality and morbidity from measles in the last decade, outbreaks continue to occur in some parts of the world including Nigeria.Objective: To determine antibody response to routine measles vaccinationin Nigerian children and evaluate vaccine potency.Methods: A prospective study of 234 children selected from 3 health centres in an urban area of Lagos, Nigeria. Blood was obtained before and 8-12 weeks after routine vaccination with Edmonston-Zagreb strain of measles vaccine. Antibodies were detected using the measles antibody neutralization test. Reconstituted vaccines samples were analysed forpotency on monolayers of Vero slam cells in 96-well tissue culture plates.Results: Twenty seven(11.5%) had pre-vaccination antibodies. Seroconversion rate among the 195 who returned for postvaccinationsampling was 69.2%: It was however 74.2% in children with no pre-vaccination antibodies compared to 17.6% in those with antibodies. (p<0.05). Only six (50%) of the measles vaccine vials were potent. Seroconversion rate among subjects vaccinated from potent vials was 74.3% compared with 42.9% in those vaccinated from non-potent vials (p = 0.006).Conclusion: Seroconversion to measles vaccination in our environmentis sub-optimal, partly attributable to low vaccine potency. Improvement of vaccine handling processes and booster doses of the vaccine are recommended.

There are no comments yet on this publication. Be the first to share your thoughts.