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Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis.

Authors
  • 1
Type
Published Article
Journal
Arthritis research & therapy
1478-6362
Publication Date
Volume
11
Issue
5
Identifiers
DOI: 10.1186/ar2824
PMID: 19804628
Source
Medline

Abstract

This study demonstrates for the first time an expansion of activated switch memory B cells and of IgG-secreting plasma blasts in the SF from oligoarticular JIA patients. Memory B cells belonged to either the CD27+or the CD27- subsets and expressed CD86, suggesting their involvement in antigen presentation to T cells. Patterns of chemokines-receptor expression on CD27+ and CD27- switch memory B cells delineated potential mechanisms for their recruitment to the inflamed joints.

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