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Direct detection of acetaminophen in urine by liquid chromatography with electrochemical detection using dual electrodes. Preliminary application to a single-dose pharmacokinetic study

Authors
Journal
Analytica Chimica Acta
0003-2670
Publisher
Elsevier
Publication Date
Volume
236
Identifiers
DOI: 10.1016/s0003-2670(00)83325-5
Keywords
  • Acetaminophen
  • Urine
Disciplines
  • Pharmacology

Abstract

Abstract A method for the direct determination of acetaminophen in urine based on liquid chromatography with series dual-electrode detection has been developed. No sample pretreatment steps are required except for filtration. The method gives a linear range from 0.5 to 300 μg ml −1 and a detection limit of 0.2 μg ml −1 (10 μl). The analysis time of the assay is less than 7 min. The pharmacokinetics of acetaminophen in urine from a subject who had orally ingested 450 mg (table form) of the drug were studied and various pharmacokinetic parameters were determined.

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