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[3H]Leu-enkephalin binding following chronic swim-stress in mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
36
Issue
3
Identifiers
DOI: 10.1016/0304-3940(83)90020-4
Keywords
  • Enkephalins
  • Opiate Receptor
  • Stress
  • Chronic Stress
  • Binding Sites
  • Antinociception
  • Endogenous Opiates

Abstract

Abstract Warm water swimming produces in mice an opiate-like antinociceptive response. Chronic swimming produces tolerance to the antinociceptive response and, depending on the schedule, cross-tolerance with morphine and naloxone intensified withdrawal signs. Low affinity [ 3H]Leu-enkephalin binding to brain homogenates at low temperature was significantly reduced in acutely swum mice and chronically swum mice whether or not they were swum. Preincubation at 37°C abolished all between-group differences. Results following chronic swimming were similar whether or not the schedule produced morphine cross-tolerance. These results were discussed in terms of the interpretation that reduced binding reflects increased in vivo occupation of opioid binding sites.

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