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Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Volume
54
Identifiers
DOI: 10.1016/j.ejmech.2012.04.037
Keywords
  • Friedelan Triterpenoid
  • 3D Molecular Docking
  • Topoisomerase Iiα Inhibition
Disciplines
  • Biology
  • Design

Abstract

Graphical abstract First report of antitopoisomerase activity of friedelans and their 3D molecular docking on topoisomerase. Highlights ► Very first report of toisomerase inhibitory activity of the friedelan derivatives. ► 3D molecular docking on topoisomerase IIα (1 bgw, PDB). ► Prediction of nature of interactions of the drug molecules with enzyme. ► Helpful for drug designing and mechanism of drug resistance phenomena. ► Prediction of dose dependent inhibition activity against topoisomerase IIα.

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