Graphical abstract First report of antitopoisomerase activity of friedelans and their 3D molecular docking on topoisomerase. Highlights ► Very first report of toisomerase inhibitory activity of the friedelan derivatives. ► 3D molecular docking on topoisomerase IIα (1 bgw, PDB). ► Prediction of nature of interactions of the drug molecules with enzyme. ► Helpful for drug designing and mechanism of drug resistance phenomena. ► Prediction of dose dependent inhibition activity against topoisomerase IIα.