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Substances released by trypsin potentiating bradykinin action on smooth muscle

Authors
Journal
Pharmacological Research Communications
0031-6989
Publisher
Elsevier
Publication Date
Volume
6
Issue
4
Identifiers
DOI: 10.1016/s0031-6989(74)80030-5

Abstract

Summary The nature of the sensitizing substances, responsible of overestimation in bradykinin bioassay, was investigated by comparing the potentiation caused by trypsin, plasma hydrolysates and BAL (2,3-dimercapto-1-propanol), on the response of guinea-pig ileum to bradykinin. From the different pattern of action of BAL and trypsin and from the kind of their action, it was established that the sensitization caused by trypsin was similar to that shown by plasma hydrolysates and that it could not be related to kininase inhibition. Trypsin, after an initial selective sensitization to bradykinin, unspecifically damaged the preparation. It was suggested that trypsin enhanced bradykinin effect on the ileum through the release of polypeptides and, probably, other substances from the tissue used for the bioassay.

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