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Native α2-macroglobulin binds to a surface component of human placental trophoblast

Authors
Journal
Placenta
0143-4004
Publisher
Elsevier
Publication Date
Volume
6
Issue
4
Identifiers
DOI: 10.1016/s0143-4004(85)80041-2

Abstract

Summary Immunofluorescence and radiobinding studies have shown that native human α 2-macroglobulin (α 2M), but not α 2M-trypsin complexes, binds to isolated human placental syncytiotrophoblast microvillous plasma membrane vesicles. Inhibition studies have indicated tha α 2 M may bind to a trophoblast surface protease. This interaction is of significance for the control of trophoblast invasiveness and haemostasis within the placental bed.

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