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Synthesis, structures and DNA binding of ternary transition metal complexes M(II)L with the 2,2′-bipyridylamine (L = p-aminobenzenecarboxylic acid, M = Ni, Cu and Zn)

Authors
Journal
Inorganica Chimica Acta
0020-1693
Publisher
Elsevier
Publication Date
Volume
362
Issue
2
Identifiers
DOI: 10.1016/j.ica.2008.04.017
Keywords
  • Glycosidase Inhibitors
  • Spiro Compounds
  • Imidazoline
  • Carbocyclic Compounds

Abstract

Abstract New ternary transition metal complexes of formulations [Ni(bpa)( p-AB)Cl] n · 3 nH 2O (bpa = 2,2′-bipyridylamine, p-AB = aminobenzenecarboxylic acid) ( 1), [Cu(bpa)( p-AB)Cl] · H 2O ( 2), [Zn(bpa)( p-AB) 2] · H 2O ( 3) are prepared, their structural features are characterized by crystal structural studies, and their DNA binding propensity has been evaluated by fluorescence and viscosity method. In complex 2 and 3, both bpa and p-AB act as the bidentate N and O-donor ligand, respectively. While in complex 1, p-AB acts as a rare tridentate ligand. In the packing pattern of each complex, π–π interaction in their solid state is also described. The complexes show the competitive inhibition of ethidium binding to DNA, and the DNA binding propensity can be reflected as the relative order: 1 > 2 > 3.

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