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Thiostrepton: A ribosomal inhibitor of translocation

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
40
Issue
3
Identifiers
DOI: 10.1016/0006-291x(70)90956-3
Disciplines
  • Biology

Abstract

Abstract The peptide antibiotic thiostrepton inhibits translocation through inhibition of a 50S subunit function which is linked to or a part of the events involved in translocation. The antibiotic does not significantly inhibit aminoacyl-tRNA binding to ribosomes or peptide bond formation at concentrations which inhibit protein biosynthesis and translocation greater than 90%.

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