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Synthesis of diarylmethane derivatives from Pd-catalyzed cross-coupling reactions of benzylic halides with arylboronic acids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
45
Issue
44
Identifiers
DOI: 10.1016/j.tetlet.2004.09.020
Keywords
  • Benzylic Halides
  • Suzuki Cross-Coupling Reaction
  • Diarylmethanes

Abstract

Abstract A simple catalyst precursor prepared in situ from palladium acetate and triphenylphosphine shows high activity for the Suzuki cross-coupling reaction of benzylic bromides and chlorides with aryl boronic acids. The reaction can be carried out at low catalyst loading (0.002–1 mol%) and under mild conditions (room temperature to 80 °C) furnishing diarylmethane derivatives in high yields (86–99%).

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