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IgE: an immunoglobulin specialized in antigen capture?

Authors
Journal
Immunology Today
0167-5699
Publisher
Elsevier
Publication Date
Volume
11
Identifiers
DOI: 10.1016/0167-5699(90)90172-6

Abstract

Abstract IgE bound to the low-affinity receptor for immunoglobulin E (FcϵR) on antigen-presenting cells (APCs) may permit binding of antigens to APCs prior to their processing and presentation. Here, G.C. Mudde and colleagues argue that the unique characteristics of IgE serological responses together with the distribution of FcϵR 11 (CD23) on APCs are consistent with this novel function of IgE. The concept of IgE involvement in antigen capture is discussed in relation to Langerhans cells, B cells and follicular dendritic cells.

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